What are Estilad Mesobotox PhytoCellTec™ stem cells?

Skin aging is a complex process which involves all the layers of the epidermis and dermis. In order to slow skin aging, methods are researched which would strengthen and protect skin stem cells. Science is in search of the right method to stimulate the proliferation of epidermal stem cells. Plant stem cells show outstanding anti-aging properties, as they can, among other activities, stimulate fibroblasts to synthesise collagen, which, in turn, stimulates skin regeneration.

Estilad Mesobotox with Stem Cells contains PhytoCellTec™ stem cells.

PhytoCellTec™ (Malus Domestica) is a patented liposomal preparation of apple stem cells derived from the ‘Uttwiler Spätlauber’, a rare Swiss apple variety. These apple stem cells are rich in epigenetic factors and metabolites, which ensures the longevity of skin cells. PhytoCellTec™ Malus Domestica has been shown to protect skin stem cells while also delaying the senescence of hair follicles. PhytoCellTec™ Malus Domestica succeeds in delivering a revolutionary anti-aging performance for real rejuvenation.

Mibelle Biochemistry has developed a novel plant cell culture technology (PhytoCellTec™) that enables the large-scale cultivation of callus (stem) cells from rare and protected plant species, such as Malus Domestica. The PhytoCellTec™ technology, which was recognized at the UN Conference Rio+20 as an Eco breakthrough, delivers a highly sustainable sourcing of this active.

PhytoCellTec™ Malus Domestica was the first ingredient based on plant stem cells on the cosmetic market. The topical use of PhytoCellTec™ Malus Domestica is patented in the USA (US 9,155,916 B2 / US 8,580,320 B2) and in Korea (10-1470632).


  • Increases the colony forming efficiency of epidermal stem cells
  • Helps skin cells to maintain the capacity to build new tissues (3D epidermis)
  • Reverses signs of senescence in fibroblasts
  • Increases lifespan of isolated hair follicles
  • Anti-wrinkle effect on crow’s feet



  • Protects longevity of skin stem cells
  • Delays senescence of essential cells
  • Increases the vitality of skin stem cells
  • Combats chronological aging



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